Otitis media revealing a congenital tuberculosisis in preterm neonate: a case report

Mariam Erradi, Neonatal Intensive Care Unit and Neonatology Department Hospital Mother-Child - Hassan II CHU of Fes Faculty of Medicine, Pharmacy, and Dentistry of Fes - Sidi Mohamed Ben Abdellah University, Km 2.200 Route Sidi Harazem, P.O. Box 1893, 30070 Fes, Morocco.

Abstract
Congenital tuberculosis is rare and fatal. The delay in diagnosis is very common in most cases. We report a premature infant born after 30 weeks of gestation; the diagnosis was suspected in front of otorrhea at 5 weeks of life with the announcement of the death of the mother following multifocal tuberculosis. The mycobacterium tuberculosis was isolated in direct examination of needle biopsy (cytopunction) of cervical lymphadenopathy; the infant had received antibacillary treatment for 12 months according to the national protocol; no index case in the family was objectified. The infant was treated, and he is recovering with good clinical evolution. This case raises the difficulty of diagnosing tuberculosis in the neonatal period as well as the interest of establishing in our context a strategy for screening nosocomial infections of tuberculosis in an inpatient setting.

Keywords
Congenital tuberculosisis, preterm, otitis media, diagnosis, case report

Cite this paper
Mariam Erradi, Otitis media revealing a congenital tuberculosisis in preterm neonate: a case report , SCIREA Journal of Clinical Medicine. Volume 9, Issue 1, February 2024 | PP. 27-33. 10.54647/cm321239

References

[ 1 ]	Locham Jaideep, Chandra Shaw Subhash, Dalal SS, Gupta Rakesh. Congenital tuberculosis in a neonate. Med J Armed Forces India. 2019; 75(1):96-98.
[ 2 ]	Peng Wansheng, Yang Juan, Liu Enmei. Analysis of 170 cases of congenital TB reported in the literature between 1946 and 2009. Pediatr Pulmonal 2011; 46:1215e24.
[ 3 ]	Tamura Kentaro, Kawasuji Hitoshi, Tachi Sayaka, Kawasaki Yukako, Nagaoka Mitsuhide, Makimoto Masami, Sakamaki Ippei, Yamamoto Yoshihiro, Kanatani Junichi, Isobe Junko, Mitarai Satoshi, Yoneda Noriko, Yoneda Satoshi, Saito Shigeru, Yoshida Taketoshi. Congenital tuberculosis in an extremely preterm infant and prevention of nosocomial infection. J Infect Chemother. 2019; 25(9):727-730.
[ 4 ]	Espiritu Nora, Aguirre Lino, Jave Oswaldo, Sanchez Luis, Kirwan Daniela E, Gilman Robert H. Congenital transmission of multidrug-resistant tuberculosis. Am J Trop Med Hyg. 2014; 91(1):92–95.
[ 5 ]	World Health Organization. https://www.who.int/fr/news/item/17-01-2023-who-announces-plans-to-establish-a-tb-vaccine-accelerator-council [ Accessed 23 june 2023]
[ 6 ]	Sanchez Pablo J, Patterson Janna C, Ahmed Adil. Congenital tuberculosis. In: Gleason CA, Devaskar SU, editors. Avery's diseases of the newborn. 9th ed. Philadelphia: Elsevier Saunders; 2012. p. 529e37.
[ 7 ]	World Health Organization. Global Tuberculosis Report 2018. Geneva, 2018.
[ 8 ]	Skevaki Chrysanthi, Kafetzis Dimitrios. Tuberculosis in neonates and infants: epidemiology, pathogenesis, clinical manifestations, diagnosis, and management issues. Pediatr Drugs. 2005; 7: 219-234.
[ 9 ]	Cantwell Michael F, Shehab Ziad M, Costella Andrea M, et al. Brief report: congenital tuberculosis. N Engl J Med. 1994; 330: 1051 – 1054.
[ 10 ]	Desi M Newberry , Tracey Robertson Bell. Congenital Tuberculosis: A New Concern in the Neonatal Intensive Care Unit. Adv Neonatal Care 2018; 18(5):341-349