Conglomerate and Analgesic Activity of 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one from 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one.

Volume 9, Issue 1, February 2024     |     PP. 1-12      |     PDF (343 K)    |     Pub. Date: March 5, 2024
DOI: 10.54647/materials430259    27 Downloads     106254 Views  


Osarumwense Peter Osarodion, Department of Chemical Science, Ondo State University of Science and Technology, Okitipupa, Ondo State, Nigeria.

Introduction: Quinazolinone by–product disclosed various curative characteristics such as analgesic, anti-inflammatory and anticancer activities, as well as antimicrobial activity. These heterocycles are beneficial intermediates in organic synthesis. Methods/Experimental:The compound, 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one(1) was integrated by dissolving 5-bromo anthranillic acid in 100 ml of pyridine. To this reaction mixture o-amino benzoyl chloride stirring at room temperature for 30 minutes this was refluxed with 75 mL of hydrazine hydrate for 3 hrs at 120-1300C. the reaction mixture was allowed to cool to room temperature to give 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one (2). These Compounds were evaluated for their analgesic activity using Acetic acid induced model. Study Design: This study was experimentally design and the analgesic activity was evaluated using Acetic acid induced model. Result: The compounds synthesized were evaluated pharmacologically for their in-vivo analgesic activities by acetic acid induced writhing in mice. The two scrutinized compounds exhibited significant analgesic activity in the range of 61.33 - 83.18% in comparison to control. Conclusions: From our findings, compound 2 synthesized have higher analgesic activities as compared to indomethacin a standard analgesic drug.

Analgesic activity; Coglomerate; Quinazolinone derivatives; 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one; 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one.

Cite this paper
Osarumwense Peter Osarodion, Conglomerate and Analgesic Activity of 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one from 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one. , SCIREA Journal of Materials. Volume 9, Issue 1, February 2024 | PP. 1-12. 10.54647/materials430259


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